Is timing of BP medication important?
Interesting results from a chronotherapy study on BP medication were published in the European Heart Journal recently, showing that it may be better to take antihypertensives at bedtime.
Ramon Hermida and colleagues looked at morning vs evening dosing of blood pressure medication. Their study in a primary care clinical setting aimed to validate a previous smaller study which showed improved asleep BP and a lower incidence of cardiovascular events with night time dosing of medication.
A total of 19 168 patients were randomised to exclusive morning or evening treatment with 1 or more BP medications and followed up for a median period of 6.3 years. Patients on the bedtime regimen showed significantly lower asleep BP, but not awake BP.
Patients in the bedtime arm also showed a significantly lower hazard ratio for the primary cardiovascular outcome (myocardial infarction, coronary revascularization, heart failure, stroke, death due to CVD). The bedtime regimen also demonstrated a similar safety profile to the morning dose arm.
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