Loperamide is an antidiarrhoeal that has been available over the counter for many years. It is a µ-opioid receptor agonist that inhibits intestinal peristalsis. After oral ingestion it has poor systemic bio-availability and poor blood-brain barrier penetration. Adverse effects are generally mild and short courses do not result in withdrawal symptoms. Due to these factors it was assessed as having low abuse potential.
We’re just back from the Eastern Cape leg of the road trip to promote the National HIV & TB Health Care Worker Hotline. Over 1 500 km and more than fifty clinic/hospital visits and poster drop-offs took us from East London to Aliwal North, the Karoo and back down to fly out of Port Elizabeth, over a 10-day period.